This unprecedented condition for mankind made the World Health Organization (WHO) declare the virus as a pandemic on Ma.Īlthough COVID-19 impacts all age groups, it is more prevalent in male patients with fatal outcomes in cases with comorbidities such as hypertension, diabetes, and obesity. COVID-19 outbreak has become a pandemic with an impact on all social and economic activities throughout the world due to the high mortality rates threatening the global public health with even catastrophic influence felt worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) labeled as the coronavirus disease (COVID-19) broke out in Wuhan, China in December 2019. Although the proposed underlying mechanisms partly fail to answer the questions by which COVID-19 leads to ED, it is important to monitor men who recovered from COVID-19 regarding the sexual dysfunction sequelae of infection and address the long‐term consequences. Current evidence illuminates endothelial dysfunction, direct testicular damage, and the psychological burden of COVID-19 that are of the pathways of ED. In this narrative review, we aimed to gather possible mechanisms of the development of ED led by COVID-19. Besides, male reproductive organs have been reported to be affected by the especially severe disease, resulting in erectile dysfunction (ED). Androgens may be responsible for the underlying reason of more severe disease, as androgen receptors have been implicated to mediate viral cell entry and infection. COVID-19 affected men more than women, emerging with more severe disease and higher mortality rates. The novel severe acute respiratory syndrome coronavirus 2 caused the coronavirus 2019 (COVID-19) pandemic that resulted in more than 150 million infections and 3.5 million deaths globally.
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